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    Potential side effects of Spedra

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      How Spedra works

      Spedra is a fast acting medicine used to treat erectile dysfunction. By helping relax the smooth muscle cells in the blood vessels supplying the penis it increases the blood flow and helps create an erection. However, like all medicines, Spedra comes with certain side effects. Nevertheless, they will not happen to everyone, and usually the side effects are mild to non existent.

      Side effects

      Common (affect between 1 in 10 and 1 in 100 people)

      • Nasal congestion
      • Headaches
      • Flushing

      Uncommon (affect between 1 in 100 and 1 in 1000 people)

      • Dizziness
      • Nausea
      • Tiredness
      • Headache
      • Blurred vision
      • Heart palpitations and increased heart rate
      • Back pain
      • Hot flushes
      • Congested sinuses
      • Stomach pains
      • Vomiting
      • Muscle tiredness
      • General fatigue

      Rare (affect between 1 in 1000 and 1 in 10,000 people)

      • Diarrhoea
      • Dry mouth
      • Insomnia
      • Gout
      • Seasonal allergy
      • Premature ejaculation
      • Increased heart rate (tachycardia)
      • Hypertension (high blood pressure)
      • Upper respiratory tract congestion
      • Angina
      • Mood swings
      • Weight gain
      • Gastritis (inflamed lining of the stomach)
      • Lower abdominal pain
      • Back pain
      • Muscle spasms
      • Spontaneous penile erections
      • Pruritus (itchiness)
      • Penile irritations
      • Influenza
      • Chest pains
      • Asthenia/extreme tiredness
      • Increased blood pressure
      • Blood in your urine
      • Heart murmurs
      • Increased body temperature
      • Prostate specific antigen increased (protein produced by your prostate)
      • Blood creatinine levels increased

      How to decrease the risk of Spedra side effects

      • Avoid alcohol - Drinking more than one or two units of alcohol may alter the speed of onset and effectiveness of Spedra. Similarly, this might increase your risk of developing side effects.
      • Avoid recreational drugs - Recreational drugs like ‘Room Odourisers’ and ‘Poppers’ (Amyl nitrate) contain nitrates which can cause side effects when taken alongside Spedra. Other recreational drugs can cause serious reactions. If in doubt, avoid them altogether.
      • Take a lower dose - Taking a lower dose will decrease the likelihood of developing side effects. This may reduce the effects of Spedra. It is always best to consult your doctor first if you plan on changing your prescribed dose, or taking other medicines alongside Spedra.
      • Avoid taking with food - Spedra is most effective when taken on an empty stomach. Taking it with food will slow down its effectiveness, but could reduce the possibility of side effects.
      • Check prescription medicines interactions with Spedra - Due to Spedra’s effect on the cardiovascular system, some prescription medicines will not interact well with Spedra. Doing so may increase the risk of side effects, possibly leading to fatal results. If you are taking or plan to take other medicines, consult your LloydsPharmacy doctor first via your Patient Record to ensure it does not expose you to other risks.


      Spedra is a more targeted ED treatment and therefore for some men it has been clinically proven to take effect in less than 20 minutes. It also has a lower frequency of reported side effects due to its more direct mode of action.

      For most men using Spedra, the benefits of this fast acting pill outweigh the possibility of side effects, nevertheless if you have any further queries regarding side effects, please contact your LloydsPharmacy doctor.

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