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    Doxycycline and Epiduo gel

    On this page

    How do I take Doxycycline and apply Epiduo gel?

    Doxycycline must be taken with lots of water, preferably with a meal and always while you are sat or stood up.

    Epiduo gel should be applied in a thin layer to the affected area once a day. Apply it after washing and drying the face and prior to going to bed. Make sure you wash your hands thoroughly after applying as it will bleach fabric, towels and hair.

    How do Doxycycline and Epiduo work?

    Doxycycline is an antibiotic that works to kill the bacteria that cause acne. Epiduo gel contains both Adapalene and Benzoyl Peroxide, meaning it works in two different veins.  

    Adapalene is a retinoid and works to breakdown blackheads and whiteheads, reduce inflammation and prevent the formation of microcomedones (the precursor to acne lesions). Benzoyl Peroxide softens and peels the outer layer of skin, as well as killing acne-causing bacteria.

    Will this combination treatment be effective?

    For people who experience pustules (small red bumps filled with pus), nodules and cysts (larger lumps) this combination of medications is likely to be effective. Breaking down skin processes that produce acne, coupled with its antibacterial action makes it a rounded treatment for those experiencing mild to moderate acne.

    Are there any side effects to taking Doxycycline or applying Epiduo gel?

    Both these medications are likely to make the skin more sensitive to the sun, so it is important you protect yourself from sunlight and use a suitable sun cream.

    Doxycycline causes side effects in some people including nausea, tummy pain, shortness of breath, racing heartbeat and dizziness when standing up. Epiduo can also cause side effects, the most common being a mild burning sensation, redness, dryness and peeling of the affected area.

    For full information on side effects and correct use, see the Doxycycline and Epiduo patient information leaflets.

    Is it safe to take Doxycycline or apply Epiduo gel during pregnancy or breastfeeding?

    Neither Doxycycline or Epiduo gel should be used whilst pregnant or breastfeeding.

    Will this treatment interact with other medication?

    Doxycycline may interfere with the effectiveness of other medications so make sure you let our clinicians know about any other medications you may be taking.

    You should avoid any acne products that contain Benzoyl Peroxide or retinoids while you are using Epiduo gel, the same goes for cosmetics that irritate, dry or exfoliate the skin.

    Alternative acne treatments

    Instead of taking oral antibiotics, some women may be prescribed the oral contraceptive Co-cyprindiol alongside a cream or gel to treat their acne. Some people who experience acne may just prescribed a cream or gel alone. 

    Reordering treatment

    We will contact you through your Patient Record 6 weeks from your order to see how you are getting on with the medication. We may ask for some photos at this time as well to assess the response to treatment. It will also be an opportunity for you to give us feedback on your acne. To reorder your treatment, go to your Patient Record and select ‘reorder’. You will be required to fill in the online questionnaire each time you reorder.

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    How our service works

    1. Complete our simple, confidential online consultation

      5 mins

    2. One of our clinicians confirms your suitability and notifies you by email

      About 30 mins (Mon-Sun 9am-5pm)

    3. Choose delivery or collection

      Next day delivery

      Collect in your local ParcelShop​​​​​​​

    What our patients say

    Meet our clinical team

    Based in our London office, our doctors and independent pharmacists have years of experience caring for patients in NHS hospitals, GP surgeries or in community pharmacies. Any one of the team may provide you with advice, your prescription or aftercare via private message.

    Meet the whole team
    • Dr Kieran Seyan  - Meet the clinical team at LloydsPharmacy Online Doctor

      Dr Kieran Seyan

      GMC: 6104204

    • Dr Gigi Taguri  - Meet the clinical team at LloydsPharmacy Online Doctor

      Dr Gigi Taguri

      GMC: 6129350

    • Dr Mitra Dutt- Meet the clinical team at LloydsPharmacy Online Doctor

      Dr Mitra Dutt

      GMC: 6077868

    • Dr Neel Patel

      Dr Neel Patel

      GMC: 7085151

    Meet the whole team

    Delivery & collection information

    • Standard delivery


      Delivered within 2-3 working days.

    • Next-day delivery


      Orders approved before 5pm Monday-Friday will arrive within 1-2 working days. Orders approved between 5pm Friday and 12pm Sunday will usually arrive on Monday or Tuesday.

    • Standard ParcelShop collection


      Collect from 7000+ convenient ParcelShops in 2-3 working days.

    • Next day ParcelShop collection


      Collect next day from 7000+ convenient ParcelShop locations, if approved before 5pm Monday-Friday. Saturday and Sunday orders, collect Monday if approved before 12pm Sunday or Tuesday if ordered after 12pm. 

    • London same-day collection


      Order before 5pm Monday-Friday to collect in pharmacy the same day. Subject to the availability of your treatment in your selected London pharmacy.

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        LloydsPharmacy Online Doctor

        This service operates in the United Kingdom only

        LloydsPharmacy Online Doctor

        This service operates in the United Kingdom only

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        LloydsPharmacy Online Doctor

        This service operates in the Republic of Ireland only

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