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    Co-cyprindiol and Adapalene Gel

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    How do I take Co-cyprindiol and Adapalene gel?

    Co-cyprindiol (often known as Dianette or Clairette) is to be started by women on the first day of their period, then taken for 21 consecutive days, followed by a 7-day break. Co-cyprindiol will also act as a contraceptive as well as treat your acne, provided you take it correctly. You should use the Adapalene gel (generic Differin) alongside Co-cyprindiol, daily applying a thin layer of the acne treatment to the affected area.  

    To get the most of your acne treatment, you should take the pill at the same time each day and ensure you are applying Adapalene gel every night.

    How does this combination acne treatment work?

    The combination of contraceptive pill Co-cyprindiol and topical Adapalene gel deals with acne from two different angles.

    Co-cyprindiol contains cyproterone with ethinylestradiol which helps to block the hormones that cause acne, therefore preventing acne from forming.

    Adapalene gel is a retinoid and gets to work on the redness and inflammation caused by acne. It unblocks pores and reduces blackheads and whiteheads.

    Is the combination of Co-cyprindiol and Adapalene effective?

    The two-pronged action of this combination treatment means that it can be very effective in treating acne.

    This combination is particularly effective for those who experience comedogenic acne (blackheads and whiteheads) and small red, sore spots called papules. It can take 4 to 12 weeks before you start to see any change to your skin.

    Are there any side effects of Co-cyprindiol or Adapalene?

    Some women taking Co-cyprindiol may experience nausea, changes to body weight, headaches, changes to mood and breast tenderness. Adapalene gel can cause dry skin, irritation to the affected area, burning sensation and redness.

    For full information on side effects and correct use, see the Co-cyprindiol and Adapalene gel patient information leaflets.

    Is it safe to apply Adapalene when pregnant or breastfeeding?

    Neither Co-cyprindiol or Adapalene gel should be used while pregnant or breastfeeding.

    Will this treatment interact with other medication?

    Topical acne treatments can be used alongside this combination, but they should be applied at different times to the Adapalene gel and should not contain tretinoin, isotretinoin or tazarotene.

    Other medications may interfere with the effectiveness of Co-cyprindiol and its ability to protect against pregnancy. You should tell us about any other medications you are taking to ensure we prescribe safely the most suitable acne treatment.

    Alternative treatments for acne

    Instead of the contraceptive pill Co-cyprindiol, you could be prescribed oral antibiotics to treat your acne alongside a topical gel or cream. Topical medications could also be prescribed alone.

    Reordering treatment

    We will contact you through your Patient Record 6 weeks from your order to see how you are getting on with the medication. We may ask for some photos at this time as well to assess the response to treatment. It will also be an opportunity for you to give us feedback on your acne. To reorder your treatment, go to your Patient Record and select ‘reorder’. You will be required to fill in the online questionnaire each time you reorder.

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    How our service works

    1. Complete our simple, confidential online consultation

      5 mins

    2. One of our clinicians confirms your suitability and notifies you by email

      About 30 mins (Mon-Sun 9am-5pm)

    3. Choose delivery or collection

      Next day delivery

      Collect in your local ParcelShop​​​​​​​

    What our patients say

    Meet our clinical team

    Based in our London office, our doctors and independent pharmacists have years of experience caring for patients in NHS hospitals, GP surgeries or in community pharmacies. Any one of the team may provide you with advice, your prescription or aftercare via private message.

    Meet the whole team
    • Dr Kieran Seyan  - Meet the clinical team at LloydsPharmacy Online Doctor

      Dr Kieran Seyan

      GMC: 6104204

    • Dr Gigi Taguri  - Meet the clinical team at LloydsPharmacy Online Doctor

      Dr Gigi Taguri

      GMC: 6129350

    • Dr Mitra Dutt- Meet the clinical team at LloydsPharmacy Online Doctor

      Dr Mitra Dutt

      GMC: 6077868

    • Dr Neel Patel

      Dr Neel Patel

      GMC: 7085151

    Meet the whole team

    Delivery & collection information

    • Standard delivery


      Delivered within 2-3 working days.

    • Next-day delivery


      Orders approved before 5pm Monday-Friday will arrive within 1-2 working days. Orders approved between 5pm Friday and 12pm Sunday will usually arrive on Monday or Tuesday.

    • Standard ParcelShop collection


      Collect from 7000+ convenient ParcelShops in 2-3 working days.

    • Next day ParcelShop collection


      Collect next day from 7000+ convenient ParcelShop locations, if approved before 5pm Monday-Friday. Saturday and Sunday orders, collect Monday if approved before 12pm Sunday or Tuesday if ordered after 12pm. 

    • London same-day collection


      Order before 5pm Monday-Friday to collect in pharmacy the same day. Subject to the availability of your treatment in your selected London pharmacy.

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        LloydsPharmacy Online Doctor

        This service operates in the United Kingdom only

        LloydsPharmacy Online Doctor

        This service operates in the United Kingdom only

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        This service operates in the Republic of Ireland only

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